Solution NMR resonance assignment strategies for β-barrel membrane proteins
نویسندگان
چکیده
منابع مشابه
Functional fragments of disorder in outer membrane β barrel proteins
The traditional view of "sequence-structure-function" has been amended by the discovery of intrinsically disordered proteins. Almost 50% of PDB structures are now known to have one or more regions of disorder, which are involved in diverse functions. These regions typically possess low aromatic content and sequence complexity as well as high net charge and flexibility. In this study, we examine...
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Integral membrane proteins fall into two major structural classes; they consist of individual or bundled TM -helices, or they form monomeric, dimeric, or trimeric TM -barrels. These folds are dictated by the necessity to form oriented hydrogenbonded secondary structures in the highly ordered apolar environment of the lipid bilayer. No other structural motif has yet been confirmed for membrane p...
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β-barrel membrane proteins (TMBs) perform a variety of functions in living organisms and these proteins contain β-strands as their membrane spanning segments. The membrane spanning segments of TMBs contain several charged and polar residues in contrast with a stretch of hydrophobic amino acid residues in transmembrane helical (TMH) proteins. Hence, most predictive schemes, which are successful ...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2013
ISSN: 0961-8368
DOI: 10.1002/pro.2291